T19

Dr. Bruce Hissong

Scientific Review Officer

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The special emphasis panel reviews training and career development applications in the general area tumor progression and cancer therapeutics including basic cancer mechanisms, cancer progression, and early-stage cancer therapeutic development.Review DatesA roster for the panel will be posted here, at least 30 days prior to the review meeting

Topics

• Tumor progression, metastasis, angiogenesis, tumor cell adhesion, invasion/migration, dormancy and tumor dissemination
• Molecular and cellular aspects of tumor cell heterogeneity, plasticity and epithelial-mesenchymal transitions (EMT)as they relate to tumor invasion and metastasis.
• Mechanisms of tumor dormancy and recurrence.
• Immune signaling pathways and deregulation in the tumor microenvironment (immune suppression, immune tolerance, immune surveillance, immune evasion)
• Mechanisms-of-action of emerging therapeutics at molecular, cellular, and organism levels including mechanistic validation of and functional evaluation of novel molecular targets, including multidisciplinary studies that span biochemical, structural, cellular, and in vivo characterizations

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