2024 NIH Alzheimer's Research Summit: Building a Precision Medicine Research Enterprise

2024 NIH Alzheimer's Research Summit Format and Schedule

The Summit was held as an in-person event on the NIH campus at the NIH Natcher Conference Center (Building 45). The event was available to stream via NIH Videocast .

Dates

Sept 23-25, 2024

• 8:30 a.m. - 5:30 p.m., ET (Sept 23 - 24)
• 8:30 a.m. - 4:00 p.m., ET (Sept 25)

The program was organized around 9 major topics:

• Deconstructing Disease Heterogeneity: From Molecular Subtypes to Shared Causal Mechanisms
• Enabling a Precision Environmental Health Approach to Risk Reduction and Disease Prevention
• Participants as Partners in Research
• Bridging the Preclinical to Clinical Translational Gap and Accelerating Clinical Development
• Expanding the Therapeutic Modalities: From Small Molecules to Cell-Based Therapies
• Developing Precision Combination Therapies
• Diversifying the Biomarker Toolkit
• Building a Knowledge Network for Precision Medicine
• Advancing Regulatory Science to Develop Precision Medicines

Over the course of the Summit, a global audience of researchers and the public, had an opportunity to contribute to the discussions through multiple open forum sessions.

Day 1 (Monday, September 23, 2024)

8:30 a.m. Introductory Remarks

• Lawrence Tabak, Principal Deputy Director, National Institutes of Health
• Richard Hodes, Director, National Institute on Aging
• Eliezer Masliah, Director, Division of Neuroscience, National Institute on Aging

9:00 a.m. Plenary Session

• Speakers
  • Kenneth Langa, University of Michigan
  • David Bennett, Rush University
  • Amy Kind, University of Wisconsin

10:15 a.m. Session 1 | Deconstructing Disease Heterogeneity: From Complex Genetics to Molecular Subtypes and Shared Causal Mechanisms | Co-Chairs: Nilufer Ertekin-Taner, Mayo Clinic and Michael Nagle, Eisai, Inc.

• Speakers and Panelists
  • Andrew Saykin, Indiana University
  • Andrew Singleton, National Institute on Aging
  • Nicholas Seyfried, Emory University
  • Vilas Menon, Columbia University
  • C. Dirk Keene, University of Washington
  • Henne Holstege, Amsterdam University Medical Center
  • Stacy Andersen, Boston University
  • Nicholas Schork, The Translational Genomics Research Institute
  • Catherine Kaczorowski, University of Michigan
  • Edward Huey, Brown University
  • Aliza Wingo, University of California, Davis
  • Panos Roussos, Icahn School of Medicine at Mount Sinai
  • Margaret Pericak-Vance, University of Miami
  • Philip De Jager, Columbia University
  • Marina Sirota, University of California, San Francisco
  • Kyle Travaglini, The Allen Institute for Brain Science
  • Elizabeth Head, University of California, Irvine

3:15 p.m. Session 2 | Enabling a Precision Environmental Health Approach to Risk Reduction and Disease Prevention | Co-Chairs: Amy Kind, University of Wisconsin and Gary Miller, Columbia University

• Speakers and Panelists
  • Jinkook Lee, University of Southern California
  • Chandra Muller, University of Texas at Austin
  • Rima Kaddurah-Daouk, Duke University
  • Jose Luchsinger, Columbia University
  • Gareth Howell, The Jackson Laboratory
  • Matthew Campen, University of New Mexico
  • Joan Casey, University of Washington
  • Anke Huels, Emory University
  • Stuart Lipton, Scripps Research Institute
  • Yuxia Cui, National Institute of Environmental Health Sciences
  • Diane Catellier, RTI International
  • Gayathri Dowling, National Institute on Drug Abuse

5:30 p.m. Adjourn Day 1

Day 2 (Tuesday, September 24, 2024)

8:30 a.m. Panel Session | Participants as Direct Partners in Research | Co-Chairs: Heather Snyder, Alzheimer's Association and Angela Taylor, Lewy Body Dementia Association

• Speakers and Panelists
  • Carol Turner
  • Cynthia Sierra
  • Cynthia Huling Hummel
  • Terry Hetzel
  • Sarah Walter, University of Southern California
  • Nathaniel Chin, University of Wisconsin

10:00 a.m. Session 3 | Bridging the Preclinical to Clinical Translational Gap and Accelerating Clinical Development | Co-Chairs: Stacey Rizzo, University of Pittsburgh and Peter Lansbury, Harvard University

• Speakers and Panelists
  • Allan Levey, Emory University
  • Gregory Carter, The Jackson Laboratory
  • Stacey Rizzo, University of Pittsburgh
  • Tracy Young-Pearse, Harvard University/Mass General Brigham
  • Joni Rutter, National Center for Advancing Translational Sciences
  • Aled Edwards, Structural Genomics Consortium, Toronto
  • Peter Lansbury, Harvard University
  • Bruce Lamb, Indiana University
  • Kim Green, University of California, Irvine
  • Afonso Silva, University of Pittsburgh
  • Sally Temple, Neural Stem Cell Institute
  • Priyanka Narayan, National Institute of Diabetes and Digestive and Kidney Diseases
  • Prachee Avasthi, Arcadia Science
  • Frank Longo, Stanford University

1:30 p.m. Session 4 | Expanding the Therapeutic Landscape: From Small Molecules to Cell-Based Therapies | Co-Chairs: Susan Catalano, Circle Biopharma LLC Consulting and Linda Van Eldik, University of Kentucky

• Speakers and Panelists
  • Linda Van Eldik, University of Kentucky
  • Tim Richardson, Indiana University
  • Gregory Thatcher, University of Arizona
  • Kathleen Rodgers, University of Arizona
  • Roger Lane, Ionis Pharmaceuticals
  • Susan Catalano, Circle Biopharma LLC Consulting
  • Charles Sentman, Dartmouth
  • Shijun Zhang, Virginia Commonwealth University
  • Stephen Strittmatter, Yale University
  • Rosa Canet-Aviles, California Institute for Regenerative Medicine
  • Anumantha Gounder Kanthasamy, University of Georgia

3:30 p.m. Session 5 | Developing Precision Combination Therapies | Co-Chairs: Frank Longo, Stanford University and Suzanne Craft, Wake Forest University

• Speakers and Panelists
  • Jeffrey Cummings, University of Nevada, Las Vegas
  • Laura Baker, Wake Forest University
  • Thomas Paterson, Fulcrum Neuroscience
  • Roberta Diaz Brinton, University of Arizona
  • Malene Lindholm, Stanford University
  • Sid O' Bryant, University of North Texas Health Science Center
  • Nicholas Schork, The Translational Genomics Research Institute
  • Holly Nicastro, National Institutes of Health, DPCPSI
  • Stacey Rizzo, University of Pittsburgh
  • Jacobo Mintzer, Medical University of South Carolina
  • Adam Boxer, University of California, San Francisco

5:30 p.m. Adjourn Day 2

Day 3 (Wednesday, September 25, 2024)

8:30 a.m. Session 6 | Diversifying the Biomarker Toolkit | Co-Chairs: Rhoda Au, Boston University and Donna Wilcock, Indiana University

• Speakers and Panelists
  • Michael Snyder, Stanford University
  • Rhoda Au, Boston University
  • Lee Goldstein, Boston University
  • Matthias Arnold, Helmholtz University and Duke University
  • Erik Johnson, Emory University
  • Robert Rissman, University of Southern California
  • Sudhir Srivastava, National Cancer Institute
  • Ipsit Vahia, Harvard University
  • Donna Wilcock, Indiana University
  • Nilufer Ertekin-Taner, Mayo Clinic
  • Jessica Faul, University of Michigan
  • Erin Rosenbaugh, Foundation for the National Institutes of Health

11:00 a.m. Session 7 | Building a Knowledge Network for Precision Medicine | Co-Chairs: Rima Kaddurah-Daouk, Duke University and Gustavo Jimenez-Maggiora, University of Southern California

• Speakers and Panelists
  • Mette Peters, National Institute on Aging
  • John Gallacher, Oxford University
  • Anna Greenwood, Sage Bionetworks
  • Gustavo Jimenez-Maggiora, University of Southern California
  • Maria Carrillo, Alzheimer's Association
  • Chris Swanson-Fisher, National Institute of Neurological Disorders and Stroke
  • Timothy Hohman, Vanderbilt University
  • Sarah Biber, University of Washington
  • Andrew Saykin, Indiana University
  • Eugene Hinderer, Tufts University

2:00 p.m. Panel Session | Advancing Regulatory Science to Deliver Precision Medicines | Co-Chairs: Kevin Krudys, Food & Drug Administration (FDA) and Diane Stephenson, Critical Path Institute

• Speakers and Panelists
  • Teresa Buracchio, Center for Drug Evaluation and Research/FDA
  • Michelle Campbell, Center for Drug Evaluation and Research/FDA
  • Gumei Liu, Center for Biologics Evaluation and Research/FDA
  • Raj Madabushi, Quantitative Medicine Center of Excellence/FDA

3:00 p.m. Key Takeaways from the NIA Geroscience and Cognitive Aging Summits

• Speakers
  • Stacy Carrington-Lawrence, National Institute on Aging
  • Erin Harrell, National Institute on Aging

4:00 p.m. Adjourn Day 3

Summit Virtual Meeting Day 1

The first virtual meeting was held on Sept. 23, 2024.

Summit Virtual Meeting Day 2

The second virtual meeting was held on Sept. 24, 2024.

Summit Virtual Meeting Day 3

The third virtual meeting was held on Sept. 25, 2024.